Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia

Liver Transplantation Clinical Trial

Official title:

Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01379352
• Other study ID #: 2011-04-015
• Status: Completed
• Phase: N/A
• First received: June 21, 2011
• Last updated: December 24, 2013
• Start date: June 2011
• Est. completion date: December 2011

Study information

• Verified date: December 2013
• Source: Samsung Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: South Korea: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may also be different according to the preoperative hepatic function as measured by MELD score during prehepatic phase, or graft to recipient body weight ratio (GRWR) during neohepatic phase. Therefore, the investigators are trying to investigate the difference of vecuronium requirements according to the phase of surgery or MELD score, GRWR.

Description:

The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may by further reduced during anhepatic phase of liver transplantation. And the requirements may be increased as the graft functions during neohepatic phase.

We also postulated that the requirements may be different according to the preoperative hepatic function during preanhepatic phase, and according to the graft to recipient body weight ratio (GRWR) during neohepatic phase.

Therefore, we are trying to investigate the difference of vecuronium requirements according to the phase of surgery, MELD score, GRWR.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 35
• Est. completion date: December 2011
• Est. primary completion date: December 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years to 69 Years

Eligibility

Inclusion Criteria:

• patients undergoing elective living donor liver transplantation

Exclusion Criteria:

• patients who can not undergo train-of-four test due to central or peripheral neuromuscular disease.

• patients with severe cardiopulmonary diseases.

• patients who received transfusion with more than 10 units of packed red blood cells.

• primary non-functioning graft immediately after reperfusion of the graft.

• patients who administered drugs that influences the metabolism of vecuronium (such as anticonvulsant: phenytoin, carbamazepine, primidone, sodium valproate)

• patients undergoing cadaver donor liver transplantation

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Liver Transplantation

Locations

Country	Name	City	State
Korea, Republic of	Samsung Medical Center	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Samsung Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	vecuronium requirements during preanhepatic phase	total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during preanhepatic phase	during prehepatic phase of liver transplantation	No
Primary	vecuronium requirements during anhepatic phase	total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during anhepatic phase	during anhepatic phase of liver transplantation	No
Primary	vecuronium requirements during neohepatic phase	total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during neohepatic phase	during neohepatic phase of liver transplantation	No