Antithrombin III Concentrate After Liver Transplantation

Status Completed

Clinical Trial Summary

This study was designed to demonstrate more effective administration method of AT-III in immediate post-liver transplantation period.

Clinical Trial Description

Antithrombin III(AT-III) concentrates have been used to prevent critical thrombosis in the immediate post-liver transplantation period without clear evidence regarding the optimal dose or administration scheme. The investigators retrospectively analyzed the clinical data from the patients who received liver transplantation and developed pharmacokinetic model of AT-III in the previous research. According to this study, optimal AT-III activity level will be well-maintained with smaller dose with continuous infusion than with intermittent infusion which is widely accepted way of administration currently. A prospective study was planned to show the more effective manner of AT-III concentrate administration after liver transplantation. ;

Study Design

Related Conditions & MeSH terms

Liver Transplant; Complications

Clinical Trial Details

NCT number	NCT04219579
Study type	Interventional
Source	Seoul National University Hospital
Contact
Status	Completed
Phase	N/A
Start date	January 3, 2020
Completion date	June 30, 2022

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT05818644` - Hepatic Artery Stenosis and Thrombosis After Liver Transplantation in Children
Not yet recruiting	`NCT06041490` - Adjuvant Therapy for High-risk Hepatocellular Carcinoma Post Liver Transplantation	Phase 2
Recruiting	`NCT04443322` - Durvalumab and Lenvatinib in Participants With Locally Advanced and Metastatic Hepatocellular Carcinoma ( Dulect2020-1 )	N/A
Recruiting	`NCT05081141` - HHV8 and Solid Organ Transplantation
Completed	`NCT03165916` - Study to Compare the Incidence of Biliary Complications After Liver Transplantation	N/A
Withdrawn	`NCT04216303` - Optimal A1c Control in Post Liver or Combined Liver and Kidney Transplant Recipients Who Have Diabetes Mellitus
Recruiting	`NCT04506398` - Heterogeneity and Evolution of hepatoceLlular Carcinoma in Post-transplant HCC Recurrence
Not yet recruiting	`NCT05853484` - Home-based Bimodal Lifestyle Intervention in Patients With Liver Cirrhosis Awaiting Orthotopic Liver Transplantation	N/A
Not yet recruiting	`NCT05036031` - Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study
Recruiting	`NCT05065125` - Clinical Usefulness of Digital Single-operator Cholangioscopy(SpyGlass™) for Post-liver Transplant Anastomotic Stricture
Recruiting	`NCT06060392` - Effect of Oral Semaglutide on Liver Fat and Body Composition in Liver Transplant Recipients With Diabetes Mellitus	N/A
Enrolling by invitation	`NCT05195944` - Semaglutide vs Sitagliptin	Phase 4
Completed	`NCT05255510` - Risk of Acute Kidney Injury in Living Liver Donor Surgery
Not yet recruiting	`NCT06048445` - Placement of Biliary Drainage Stent to Prevent Biliary Intestinal Anastomosis After Liver Transplantation in Children
Completed	`NCT05116748` - COVID19 Vaccine in SOT Adult Recipients
Completed	`NCT04182256` - Magnetic Spiderman for Preparation of Liver Donation	N/A
Recruiting	`NCT04327427` - Outcome Analysis of Aspirin in Liver Transplantation
Recruiting	`NCT04477967` - Design and Implementation of the Pediatric Liver Transplantation Biobank
Recruiting	`NCT05109156` - Preoperative Sepsis Timeline, Profile and Its Association With Recipient Outcome Following Live Donor Liver Transplant
Recruiting	`NCT06124209` - Use of Fibrin Sealant Patch for Vein Anastomosis During Deceased Donor Liver Transplantation- Randomized Clinical Trial	Phase 4