Clinical Trials Logo
  1. Home
  2. Liver Surgery
  3. NCT01267786
  4. Details
NCT01267786 Clinical Trial

The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery

Liver Surgery Clinical Trial

Official title:
The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01267786
Other study ID # AnesthSurg1
Secondary ID
Status Recruiting
Phase Phase 4
First received December 28, 2010
Last updated December 28, 2010
Start date December 2010

Study information
Verified date December 2010
Source Aretaieio Hospital
Contact Georgios P Fragulidis, MD
Phone +30 6072910955
Email gfragulidis@aretaieio.uoa.gr
Is FDA regulated No
Health authority Greece: Ethics Committee
Study type Interventional

Clinical Trial Summary

The aim of the study is to investigate the effect of sevoflurane and desflurane on hepatic function after ischemic/reperfusion injury and the sequence influence on renal and cardiovascular systems.

Recruitment information / eligibility
Status Recruiting
Enrollment 40
Est. completion date
Est. primary completion date December 2011
Accepts healthy volunteers No
Gender Both
Age group 30 Years to 80 Years
Eligibility Inclusion Criteria:

- Patients undergoing liver surgery

Exclusion Criteria:

- ASA IV, Cardiovascular diseases

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Intervention

Procedure:
• Liver surgery
hepatectomy

Locations
Country Name City State
Greece Aretaieio Hospital Athens Attica

Sponsors (1)
Lead Sponsor Collaborator
Aretaieio Hospital

Country where clinical trial is conducted

Greece, 

Outcome
Type Measure Description Time frame Safety issue
Primary Oxidotic stress after hepatectomy. Perioperative liver and renal biopsies and follow up with liver renal function tests plus intraoperative and postoperative cardiovascular monitoring 5 d postop. Yes
Secondary Liver and renal dysfunction liver and renal impairment due to ischemic injury 5 d Yes
See also
  Status Clinical Trial Phase
Completed NCT04092608 - Restrictive vs Goal Directed Fluid Therapy During Hepatobiliary Surgery N/A
Completed NCT02993640 - Optimization of Hepatic Hemodynamics During Liver Surgery Early Phase 1
Completed NCT05116735 - Biliary Fistula and Late Recurrence of Liver Hydatid Cyst: Role of Cysto-biliary Communication N/A
Recruiting NCT03686137 - Institut Paoli Calmettes Hepatic Surgery Database
Recruiting NCT05594641 - Lactate Clearance After RIPC in Liver Resection N/A
Active, not recruiting NCT03270917 - ORANGE SEGMENTS: Open Versus Laparoscopic Parenchymal Preserving Postero-Superior Liver Segment Resection N/A
Completed NCT03793933 - ACS-NSQIP Calculator for Liver Surgery
Completed NCT01523353 - Prehabilitation in Liver Surgery Phase 1
Completed NCT00918619 - Efficacy and Safety of Sangustop® as Haemostatic Agent Versus a Carrier-Bound Fibrin Sealant During Liver Resection Phase 4
Completed NCT02050841 - Octaplas Pediatric Plasma Replacement Trial Phase 4
Completed NCT04668391 - Anterior Quadratus Lumborum Block at the Lateral Supra-arcuate Ligament for Analgesia After Open Liver Surgery N/A
Recruiting NCT02715427 - Enhanced Recovery After Hepatic Surgery (MultiPAS). N/A