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Cryoablation Combined With Sintilimab Plus Regorafenib In Previously Treated Colorectal Cancer Liver Metastasis

Liver Metastases Clinical Trial

Official title:
A Phase II Study of Cryoablation Combined With Sintilimab Plus Regorafenib in Previously Treated Colorectal Cancer Liver Metastasis (CASTLE-03)

Clinical Trial Summary

The objective of this study is to evaluate the efficacy and safety of cryoablation combined with Sintilimab plus regorafenib for patients with colorectal cancer liver metastasis in the third-line setting.

Clinical Trial Description

Recent studies have suggested that local destruction of tumor tissue by cryoablation induced activation and maturation of dendritic cells and tumor-specific T cells by cross-presentation of tumor antigens. While pd-1 blocking antibody interferes with PD-1 mediated T-cell regulatory signaling. And combination of pd-1 blocking antibody plus regorafenib showed increased ORR in advanced colorectal cancer. Therefore, the objective of this study is to evaluate the efficacy and safety of cryoablation combined with Sintilimab plus regorafenib in previously treated colorectal cancer liver metastasis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05057052
Study type Interventional
Source Fudan University
Contact Peng Wang, MD
Phone 86-21-64175590
Email peng_wang@fudan.edu.cn
Status Recruiting
Phase Phase 2
Start date September 26, 2021
Completion date September 25, 2024
View Details
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