Liver Fibrosis Clinical Trial
Official title:
Clinical Application of Non-invasive Assessment for Staging Liver Steatosis and Liver Fibrosis
Nowadays, the morbidity of Nonalcoholic fatty liver disease (NAFLD) show ascending trend year
by year, which has become an important public health problem in China. As NAFLD can progress
to Non-alcoholic steatohepatitis (NASH), cirrhosis and Hepatocarcinoma, the identification
and quantitative evaluation of liver steatosis and its dynamic changes are crucial. While
liver biopsy is still the gold standard in the diagnosis of NAFLD, its application is limited
because of the invasive procedure.The Transient Elastography(TE) combined with the Controlled
Attenuation Parameter(CAP) is a new non-invasive diagnostic method for fatty liver and liver
fibrosis.
In order to evaluate the diagnostic value of non-invasive assessment for the degree of liver
steatosis and staging liver fibrosis, this non-invasive method will be assessed by the golden
standard of liver biopsy among 400 NAFLD patients.The treatment protocols will be decided by
doctor and patient both (treatment protocols and medicine are not required). Blood routine,
blood biochemistry, abdominal ultrasound and Transient Elastography(TE) combined with the
Controlled Attenuation Parameter(CAP) are detected during the follow-up.
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