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Optimized Treatment and Regression of HBV-induced Liver Fibrosis

Liver Fibrosis Clinical Trial

Official title:
Optimized Treatment and Regression of HBV-induced Liver Fibrosis

Clinical Trial Summary

Patients with chronic hepatitis B histologically confirmed of liver fibrosis S2/S3 (similar to metavir F2/F3, Ishak 2/3/4) are randomly assigned in a 1:1 ratio. One arm is entecavir alone for 2 years; the other is entecavir alone for the first 0.5 year, entecavir plus pegylated interferon (peg-IFN) for 1 year, entecavir for another additional 0.5 year. Patients will be assessed at baseline, at every six months for blood count, liver function test, HBVDNA, AFP, prothrombin time, thyroid function, liver ultrasonography, and Fibroscan. The second liver biopsy will be performed to evaluate regression rate of liver fibrosis 1.5 years after initial therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01938781
Study type Interventional
Source Beijing Friendship Hospital
Contact
Status Completed
Phase Phase 4
Start date June 2013
Completion date December 2016
View Details
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