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Clinical Trial Summary

Safety and Efficacy of Mesenchymal Stem Cell Transplantation for Acute-on-Chronic Liver Failure


Clinical Trial Description

Acute-on-chronic liver failure (ACLF) which occurs in patients with chronic liver disease, is a serious live-threatening disease. Currently, the clinical management, such as liver protection, anti-virus medicine, and artificial liver support, has not significantly improve the outcomes, the mortality still remains over 50%. Liver transplantation is the only effective treatment of ACLF, but this therapy is limited by the shortage of donor organs, potential surgical complications, immunological rejection and high medical costs. Mesenchymal stem cell (MSC) is one of adult stem cells, which has been suggested to play a role in amelioration of liver disease, such as: trans-differentiation of MSCs into hepatocytes, immunomodulation, inhibition of fibrosis development, protective effects on hepatic cell and restoration of hepatic cell proliferation capacity. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03863002
Study type Interventional
Source Tianjin Weikai Bioeng., Ltd.
Contact Xiuli Cong, MD, PhD
Phone +86 18512507567
Email cong_xiuli@163.com
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date October 1, 2019
Completion date October 1, 2022

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