Liver Regeneration After Liver Resection

Liver Diseases Clinical Trial

Official title:

An Observational Study of Liver Regeneration After Right Hepatectomy: Understanding the Molecular Primers of Liver Regeneration

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01220986
• Other study ID #: NDDC10/H0403/32
• Status: Recruiting
• Phase: N/A
• First received: October 13, 2010
• Last updated: October 13, 2010
• Start date: August 2010
• Est. completion date: August 2012

Study information

• Verified date: October 2010
• Source: Nottingham University Hospitals NHS Trust
• Contact: John S Hammond, BM.BS PhD
• Phone: 01159249924
• Email: john.hammond[@]nottingham.ac.uk
• Is FDA regulated: No
• Health authority: United Kingdom: Research Ethics Committee
• Study type: Observational

Clinical Trial Summary

The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy. The investigators hypothesise that liver regeneration after right hepatectomy in humans is associated with Kupffer cell activation and initiation of the innate immune response and that impaired liver regeneration, liver failure and sepsis following liver resection are associated with Kupffer cell dysfunction and an impaired innate immune response. The objectives for this study are to characterise Kupffer cell activity and the innate immune response in human liver before and after right hepatectomy.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: August 2012
• Est. primary completion date: December 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Patients requiring right hepatectomy for colorectal liver metastases

Exclusion Criteria:

• Age >75, neoadjuvant chemotherapy, recurrent disease

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Hepatectomy
• Liver Diseases

Intervention

Procedure:
• Liver biopsy
0, 30, 60, 90 min post inflow-division

Locations

Country	Name	City	State
United Kingdom	Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus	Nottingham	Nottinghamshire

Sponsors (1)

Lead Sponsor	Collaborator
Nottingham University Hospitals NHS Trust

Country where clinical trial is conducted

United Kingdom,