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NCT05036031 Clinical Trial

Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study

Liver Cirrhosis Clinical Trial

— TEA-ACLF  

Official title:
Liver Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study to Evaluate Different Criterion in Predicting Post-transplant Outcomes

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05036031
Other study ID # Renji-IIT2021091
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date September 1, 2021
Est. completion date October 31, 2021

Study information
Verified date September 2021
Source RenJi Hospital
Contact Hao Feng, MD., Ph.D.
Phone 008615000901110
Email surgeonfeng@live.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The definition and diagnostic criteria of acute-on chronic liver failure (ACLF) differed evidently between the East and the West due to the difference in the underlying etiology. Liver transplantation is the most effective treatment to reverse the progress of ACLF and improve the survival rate of patients. The purpose of this study is to explore the accuracy of the two diagnostic criteria of EASL-CLIF and APASL ACLF in assessing the survival rate of patients with liver cirrhosis after LT.

Description:

A retrospective collection and analysis of the preoperative conditions of patients with LT due to cirrhosis in a single center from January 2015 to June 2020 would be conducted, including epidemiological characteristics, etiology, clinical indicators, and short-term (28 days, 90 days) and long-term (1 year, 3 years) survival after LT.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 500
Est. completion date October 31, 2021
Est. primary completion date October 1, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - patients underwent liver transplantation for cirrhosis - The diagnosis of ACLF followed APASL and EASL-CLIF definition. Exclusion Criteria: - Patients with malignant tumor or underwent living donor liver transplantation (LDLT) were excluded.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
RenJi Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary 3 years overall survival Up to ~3 years
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