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Effect of Saccharomyces Boulardii in Patients in the Waiting List for Liver Transplant

Liver Cirrhosis Clinical Trial

Official title:
Effect of Saccharomyces Boulardii in Patients in the Waiting List for Liver Transplant

Clinical Trial Summary

The purpose of this study is to evaluate the effect of Saccharomyces boulardii in patients in the waiting list for liver transplant.

Clinical Trial Description

Increased intestinal permeability are related to the major complications of liver cirrhosis. The administration of probiotics has been suggested to improve the barrier function of the mucosa and consequently avoid the complications of the disease. The objective of this study was to evaluate the effect of Saccharomyces boulardii in patients in the waiting list for liver transplant.

Eighteen patients were treated with Saccharomyces boulardii. Intestinal permeability (lactulose/mannitol ratio) and laboratory parameters were evaluated immediately before the beginning of treatment, after a thirty-day period of treatment with probiotic and at the end of the second study month (after a thirty-day period without treatment with probiotic). Twenty healthy volunteers were also submitted for the intestinal permeability test. ;

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01762748
Study type Interventional
Source Federal University of Minas Gerais
Contact
Status Completed
Phase Phase 2
Start date January 2011
Completion date December 2012
View Details
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