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NCT01201655 Clinical Trial

Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis

Liver Cirrhosis Clinical Trial

Official title:
Multicentric Retrospective Case Control Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01201655
Other study ID # chenyong
Secondary ID
Status Recruiting
Phase N/A
First received September 13, 2010
Last updated September 13, 2010
Start date January 2010
Est. completion date December 2012

Study information
Verified date January 2010
Source Xijing Hospital
Contact Chen yong, professor
Phone 13891915509
Email cheny@fmmu.edu.cn
Is FDA regulated No
Health authority China: Food and Drug Administration
Study type Observational

Clinical Trial Summary

The purpose of this study is to investigate the impact of splenectomy coupled with portal-azygous disconnection on hepatocarcinogenesis in patients with post-hepatitic cirrhosis after hepatitis B or C virus infection by retrospective case-control study,We hope to find a new idear and method to prevent or cure HCC.

Description:

A case-control study was carried out. The factors studied include age, gender, ascites, hepatic encephalopathy, ALT, AST, TBIL, ALP, GGT, Child-Pugh classification of liver function, and history of splenectomy with portal-azygous disconnection during the treatment of portal hypertension. According to the Child-Pugh classification, these cases were graded as A, B, and C. And according to the ranges of the normal reference values of the data, they were categorized into two groups including a normal group and an abnormal group.The data mainly comes from FMMU and Xi'an jiaotong university from the year of 2002 to 2012.

Recruitment information / eligibility
Status Recruiting
Enrollment 5000
Est. completion date December 2012
Est. primary completion date December 2012
Accepts healthy volunteers No
Gender Both
Age group 20 Years to 90 Years
Eligibility Inclusion Criteria:

- after surgery

Exclusion Criteria:

- without surgery

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Related Conditions & MeSH terms

Locations
Country Name City State
China Chen yong Xi'an Shaanxi

Sponsors (3)
Lead Sponsor Collaborator
Xijing Hospital Fourth Military Medical University, Xi’an Jiaotong University College of Medicine

Country where clinical trial is conducted

China, 

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