Liver Cancer Clinical Trial
Official title:
A Phase II Study Of Epirubicin And Thalidomide In Unresectable Or Metastatic Hepatocellular Carcinoma
RATIONALE: Drugs used in chemotherapy such as epirubicin use different ways to stop tumor
cells from dividing so they stop growing or die. Thalidomide may stop the growth of
hepatocellular (liver) cancer by stopping blood flow to the tumor. Combining epirubicin with
thalidomide may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combining epirubicin with thalidomide
in treating patients who have unresectable or metastatic liver cancer.
OBJECTIVES:
- Determine the antitumor activity of epirubicin and thalidomide in patients with locally
unresectable or metastatic hepatocellular carcinoma.
- Determine the toxic effects of this regimen in these patients.
OUTLINE: Patients receive epirubicin on days 1, 8, and 15 and thalidomide on days 1-21.
Courses repeat every 28 days.
PROJECTED ACCRUAL: A total of 12 patients per year will be accrued for this study.
;
Masking: Open Label, Primary Purpose: Treatment
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