Lipidaemia Clinical Trial
Official title:
The Chemical Structure of a Lipid Determines Its Effect on Blood Lipid Profile and Appetite Regulation
Aims: To investigate whether acute ingestions of palm oil will have an effect on appetite
regulation
Design: A randomized, single blind, cross over design including 4 single study visits
separated by a week. Visit 1 is an acclimatization visit followed by visit 2,3, and 4 where
different types of fat will be given.
Population: 12 healthy males and females aged between 18 and 60 years with body mass index
(BMI) between 18.5- 29.9kg/m2 and normal fasting plasma glucose and no evidence of insulin
resistance will be recruited. No-pre existing morbidity including cardiac, hepatic or renal
disease, history of diabetes, hypertension or hyperlipidaemia.
Treatment: Acclimatization visit: At visit 1, all participants will be given a milkshake like
drink containing fat, protein and carbohydrate. A cannula will be inserted for the duration
of the study day but no blood will be taken. Studies show than during the first visit stress
response can affect the metabolic response to the study drink resulting in inaccurate
results.
Study visit 2,3,4: following the acclimatization visit, participants will attend 3 more study
visits separated by a week to test the metabolic response to the following fats: palm olein,
interesterified palm olein and soybean oil in random order. Participants will be asked to
complete a visual analogue scale questionnaire about their appetite at each time point.
Fasting and postprandial plasma glucose, insulin, appetite hormones and lipids will be
measured.
n/a