Lidocaine Clinical Trial
Official title:
Effect of Systemic Lidocaine Infusion on Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Hysterectomy in Trendelenburg Position
Verified date | March 2023 |
Source | Tanta University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
We hypothesize that intravenous lidocaine infusion may have beneficial effect to patients undergoing laparoscopic surgeries in Trendelenburg position by preventing ICP elevation.
Status | Completed |
Enrollment | 66 |
Est. completion date | January 1, 2024 |
Est. primary completion date | January 1, 2024 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 35 Years to 65 Years |
Eligibility | Inclusion Criteria: - Aged between 35 to 65 years - American society of anesthesiology (ASA) physical status I - II - Body mass index (BMI) between 18.5 to 28.0 kg/m2 - Scheduled for total laparoscopic hysterectomy taking approximately 2 h with a 30° Trendelenburg position for management of uterine fibroids or refractory dysfunctional uterine bleeding. Exclusion Criteria: 1. Patients with eye diseases, central nervous system diseases, cardiovascular diseases, cerebrovascular diseases or diabetes. 2. If these events occurred intraoperative: - Ultrasound scans or measurements failed to clearly show the structure of Optic Nerve Sheath Diameter (ONSD). - Surgical time less than 1 h. - Interruption of carbon dioxide (CO2) pneumoperitoneum and Trendelenburg position. - Peak airway pressure exceeding 35 cm H2O 3. Patients with a history of allergy to lidocaine. |
Country | Name | City | State |
---|---|---|---|
Egypt | Tanta University Hospitals | Tanta | ElGharbiaa |
Lead Sponsor | Collaborator |
---|---|
Tanta University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Optic Nerve Sheath Diameter (ONSD) | ONSD at 5 min before induction of anesthesia in supine position (T1), 5 min after CO2 pneumoperitoneum in Trendelenburg position (T2), 30 min after CO2 pneumoperitoneum in Trendelenburg position (T3), 60 min after CO2 pneumoperitoneum in Trendelenburg position (T4) and 5 min after the closure of pneumoperitoneum in supine position (T5). | 5 min before induction of anesthesia till 5 min after the closure of pneumoperitoneum | |
Secondary | Heart rate | Heart rate at 5 min before induction of anesthesia in supine position (T1), 5 min after CO2 pneumoperitoneum in Trendelenburg position (T2), 30 min after CO2 pneumoperitoneum in Trendelenburg position (T3), 60 min after CO2 pneumoperitoneum in Trendelenburg position (T4) and 5 min after the closure of pneumoperitoneum in supine position (T5). | 5 min before induction of anesthesia till 5 min after the closure of pneumoperitoneum | |
Secondary | Mean arterial blood pressure | Mean arterial blood pressure at 5 min before induction of anesthesia in supine position (T1), 5 min after CO2 pneumoperitoneum in Trendelenburg position (T2), 30 min after CO2 pneumoperitoneum in Trendelenburg position (T3), 60 min after CO2 pneumoperitoneum in Trendelenburg position (T4) and 5 min after the closure of pneumoperitoneum in supine position (T5). | 5 min before induction of anesthesia till 5 min after the closure of pneumoperitoneum | |
Secondary | The incidence of postoperative adverse reactions | The incidence of adverse reactions, such as dizziness, postoperative nausea and vomiting (PONV) and postoperative headache (POHA) within 3 hours after surgery will be recorded in both groups. | Within 3 hours after surgery |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT06355817 -
Distraction Techniques in Periocular Anesthesia: Tapping vs Vibration
|
N/A | |
Completed |
NCT01688648 -
Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
|
N/A | |
Completed |
NCT04692896 -
Effect of Different Concentrations of Lidocaine in Relieving Pain in Wide Awake Hand Surgery Using Tumescence
|
Phase 1 | |
Recruiting |
NCT06088875 -
Nebulization Versus Spray-as-You-Go Airway Topical Anesthesia Using Dexmedetomidine and Lidocaine Mixture During Awake Flexible Fiberoptic Intubation in Temporomandibular Ankylosis
|
N/A | |
Recruiting |
NCT04169854 -
Pre-emptive Topical Lidocaine 5% Plaster for Prevention of Post-craniotomy Pain
|
Phase 3 | |
Completed |
NCT04076865 -
Evaluation of the Effect Induced by Repeated Administration of Topical Local Anaesthetic (EMLA) on Itch
|
N/A | |
Completed |
NCT02987985 -
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
|
Phase 3 | |
Recruiting |
NCT05089526 -
Opioid-free Anesthesia in Laparoscopic Cholecystectomies
|
N/A | |
Recruiting |
NCT03871478 -
Comparing the Efficacy of Local Anesthetics in Mohs Surgery
|
N/A | |
Recruiting |
NCT03666299 -
Lidocaine Infusion for Postthoracotomy Pain Syndrome
|
N/A | |
Recruiting |
NCT03673163 -
Lidocaine Infusion for Pain After Herniotomy
|
N/A | |
Recruiting |
NCT05158348 -
A Comparative Study to Measure the Effect of Nebulized Dexmedetomidine
|
Phase 3 | |
Completed |
NCT06135688 -
Effects of Lidocaine Bolus and Infusion on Bispectral Index Values and Spectrum During Anesthesia Maintenance
|
||
Completed |
NCT04008433 -
Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated With Medium-/Long-chain Triglycerides
|
N/A | |
Recruiting |
NCT04622904 -
Lidocaine and Magnesium and Ketamine in Gynecological Surgery
|
N/A | |
Recruiting |
NCT05717361 -
Opioid Sparing Anesthesia in Cervical Spine Surgery
|
N/A | |
Withdrawn |
NCT04359017 -
Systemic Absorption of Lidocaine After Hematoma Block
|
Phase 4 | |
Recruiting |
NCT04144933 -
Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
|
Phase 3 | |
Recruiting |
NCT05243940 -
Opioid-free Anesthesia in Thyroidectomies
|
N/A | |
Completed |
NCT05484687 -
Effect of Intravenous Infusion of Lidocaine on Patients Undergoing Radical Resection of Colorectal Tumors
|
N/A |