Lichen Planus, Oral Clinical Trial
— RCTOfficial title:
The Efficacy of Selenium as an Alternative or Complementary Topical Treatment of Oral Lichen Planus (Randomized Clinical Trial)
evaluate clinically and biochemically the efficacy of topically applied selenium as complementary or alternative to triamcinolone acetonide 0.1% and tacrolimus 0.1% in patients with oral lichen planus.
Status | Not yet recruiting |
Enrollment | 20 |
Est. completion date | March 1, 2025 |
Est. primary completion date | October 1, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 55 Years |
Eligibility | Inclusion Criteria: - clinical diagnosis of OLP Exclusion Criteria: 1. lichenoid reaction from medication ' . 2. any systemic autoimmune disease 3. Pregnancy 4. smokers |
Country | Name | City | State |
---|---|---|---|
Egypt | Alazhar university ,faculty of Dental Medicine | Assiut |
Lead Sponsor | Collaborator |
---|---|
Al-Azhar University | Sphinx university |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | to assess a visual analog scale (VAS)of the oral lichen planus lesion | qualitative | baseline, 1, 3 and 6 months after treatment | |
Secondary | to assess The associated Oral Disease Severity Score 3- Glutathione biomarker level as an antioxidant enzyme in saliva by ELISA analysis | qualitative ,and quantitiave | baseline, 1, 3 and 6 months after treatment | |
Secondary | Biochemical evaluation of salivary Glutathione level using (ELISA) | Quantity | baseline, 1, 3 and 6 months after treatment |
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