Lichen Planus, Oral Clinical Trial
Official title:
Efficacy of Oral Lycopene in the Management of Oral Lichen Planus
the purpose of this study was to evaluate that if lycopene, a potent antioxidant can be used
in the treatment of oral lichen planus. this could be useful as lycopene has no reported
side effects and hence it can used in place of steroids which are commonly used for this
condition and have many reported adverse effects.
lycopene can be used in the treatment of this condition as free radicals have been found to
play a role in the cause of this disease and also lower levels of lycopene were seen in
these patints.
Lichen planus, a chronic inflammatory mucocutaneous disease, occurs in about 2% of the adult
population, affecting the skin and or oral mucosa. Clinically, lichen planus appears in
keratotic, atrophic or erosive form. The atrophic and erosive forms are usually symptomatic.
Various treatment modalities viz. corticosteroids, antimicrobials, immunomodulators,
phenytoin, retinoids, UV-radiation and surgical treatment etc. have been tried. Though none
of these have shown to achieve satisfactory results with recurrence of lesion occurring in
most of the cases after few weeks of discontinuation of therapy.
Recently a population based case control study has revealed lower levels of lycopene in
atrophic and erosive oral lichen planus cases, while no significant difference was noted in
any other carotenoid levels.
Lycopene is an antioxidant and free radical scavenger being used in the management of
infertility, pre-eclampsia, cataract prevention, osteoarthritis, as adjuvant therapy in
various malignancies, cardiovascular disorders, diabetes mellitus, aging, Alzheimer's
disease, parkinsonism, etc.
Systemic lycopene has been found to be effective in treatment of oral leukoplakia, owing to
its antioxidant properties.
The utility of lycopene in oral lichen planus has not been reported in the literature;
therefore, this study has been designed to assess the efficacy of systemic lycopene in
management of oral lichen planus patients.
The data collected from this study can move us closer to deriving a specific treatment plan
for oral lichen planus - a dividend, not only for patients but dental fraternity as well.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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