Clinical Trials Logo
  1. Home
  2. Lewy Body Disease
  3. NCT01944436

A Genetic and Perfusion Study of Response to Cognitive Enhancers in Lewy Body Disease

Lewy Body Disease Clinical Trial

Official title:
Lewy Body Spectrum Disorders: Investigating Neuropsychiatric Benefit and Adverse Effects in Response to Cholinesterase Inhibitors Using Genetics and Brain SPECT

Clinical Trial Summary

Lewy body spectrum disorders are a common group of neurodegenerative diseases that cause memory loss, behavioural and motor disabilities that impair quality of life. Cognitive enhancers help people afflicted with these conditions. However, some people do not benefit from this treatment, while others experience serious side effects. Side effects and poor response lead to hospitalization and early institutionalization. Pharmacogenomics, the study of how DNA variation can influence drug effects, will be combined with functional changes in brain imaging in response to cognitive enhancers in patients with Lewy body disease. The goal is to develop a predictive test that can be administered in the clinic to aid physicians' choice of initial medication. This can reduce health care costs and improve treatment to Canadians suffering from these devastating disorders.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01944436
Study type Observational
Source Sunnybrook Health Sciences Centre
Contact
Status Completed
Phase N/A
Start date September 2006
Completion date January 2016
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04436341 - Epileptic Activity in Patients With Alzheimer's Disease and Lewy Body Dementia
Not yet recruiting NCT05004558 - Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias N/A
Enrolling by invitation NCT03724136 - Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study N/A
Terminated NCT02263287 - LESCOD: "Lewy Body Screening in Cognitive Disorders" N/A
Completed NCT05188105 - Alpha tACS in Dementia With Lewy Bodies N/A
Completed NCT04649164 - Learning to PERSEVERE: Peer Mentor Support and Caregiver Education in Lewy Body Dementia N/A
Active, not recruiting NCT04148391 - NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking) Phase 2
Recruiting NCT06203106 - NYSCF Scientific Discovery Biobank
Enrolling by invitation NCT05514106 - MIBG in Aging and Neurologic Disorders Phase 4
Recruiting NCT04817891 - Stimulation of Cingulo-opercular Alertness Network N/A
Completed NCT05916664 - Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers N/A
Recruiting NCT03174938 - The Swedish BioFINDER 2 Study N/A
Recruiting NCT06389032 - PERSEVERE: Peer Mentor Support and Caregiver Education in Lewy Body Dementia N/A
Recruiting NCT05847985 - Language and Lewy Body Diseases: Sentence Comprehension Problems and Modifying Noninvasive Brain Stimulation Treatment N/A
Completed NCT04794634 - Relationship Between Alzheimer Disease and Diminution of the Three Macular Nervous Retinal Layers N/A
Recruiting NCT03472482 - Optical Coherence Tomography in Cerebral Amyloidosis
Not yet recruiting NCT00448318 - Evaluating the Effects of Music Interventions on Hospitalised People With Dementia Phase 2/Phase 3
Completed NCT02213458 - Care Ecosystem: Navigating Patients and Families Through Stages of Care N/A
Completed NCT04287738 - Care Ecosystem: Navigating Patients and Families Through Stages of Care, Extension Trial N/A
Completed NCT03076671 - More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease N/A