Lewy Body Dementia Clinical Trial
Official title:
Interest of the Combination of the DaTSCAN Scintigraphy and MRI Scan in the Differential Diagnosis of Lewy Body Dementia From Alzheimer Disease in Patients With Hallucinations
The aim of this study is to improve the diagnostic of Lewy body dementia by combining the scintigraphy (SPECT) usig a spécific transporter and magnetic resonance imaging (MRI).
Lewy body dementia is the second leading cause of dementia in France after degenerative
Alzheimer's disease.
However its dignosis is difficult. Its comes in large part from the similarity of symptoms
with another close dementia syndrome : the Alzheimer disease . Therfore, its is very
important to have a mean to distinguish between the two dementias.
One highlight of the Lewy body dementia process being dopaminergic degeneration, the use of
specific radioactive tracers is thought to be the way. The radiotracer that has the greatest
advantage for these explorations is currently the DaTSCAN because it binds specifically on
the dopamine transporter and can be used in Single photon emission computed tomography
(SPECT).
The aim of this study is to improve the performance of imaging in the diagnosis of dementia
by combining scintigraphy (SPECT) and magnetic resonance imaging (MRI) in the exploration of
the striatal region . The development of this method applied to a population of subjects,
with hallucinations and cognitive disorders, should demonstrate the value and
complementarity of metabolic images (SPECT) and morphological (MRI) within the differential
diagnosis of Lewy body dementia and the Alzheimer disease .
From a methodological point of view, the patient will be included in hospital and will have
a clinical diagnosis defined according to the criteria of dementia NINCDS-ADRDA for the
Alzheimer disease and Mc-Keith criteria for Lewy body dementia. Their MMSE will be over 18
and they have in common recurrent visual hallucinations.
After the inclusion, two steps must be distinguished, a neuropsychological evaluation stage
and an scitigraphy exploration . Before the SPECT , all patients should have an MRI.
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Intervention Model: Single Group Assignment, Primary Purpose: Diagnostic
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