Leukemia Clinical Trial
Official title:
Risk Stratification-directed Low-dose Glucocorticoid Prophylaxis for Acute GVHD After Unmanipulated Haploidentical Blood and Marrow Transplantation--a Randomized, Controlled, Clinical Trial
Hematopoietic stem cell transplantation (HSCT) is one of the best, and sometimes the only,
option for the treatment of leukemia. However, GVHD rate was still high after haploidentical
HSCT.
It was found in our previous study that CD4/CD8>=1.16、CD56bright NK>1.9×106/kg in the graft
was associated with higher risk of developing acute Graft-versus-host Disease (GVHD).
The study hypothesis:
Risk stratification-directed low-dose glucocorticoid prophylaxis for acute GVHD after
unmanipulated haploidentical blood and marrow transplantation can reduce the incidence of
acute GVHD
patients undergone haploidentical HSCT following day 5 post transplant were randomized to treated group(low-dose glucocorticoid) and controlled group(no intervention). ;
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