Leukemia Clinical Trial
Official title:
The Genetics of "Non-Response" in Adult AML
RATIONALE: Studying samples of bone marrow and blood from patients with cancer who failed
treatment may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer resistance. It may also help doctors find better ways to treat
cancer.
PURPOSE: This research trial studies biomarkers in samples from adult patients with acute
myeloid leukemia who failed standard-of-care treatment.
OBJECTIVES:
- Define a "non-response" signature that will help up-front identification of cases of
intermediate-risk acute myeloid leukemia (AML) destined to fail existing
standard-of-care therapy.
- Identify biological pathways in the "non-response" group that can provide targets for
novel therapeutics.
OUTLINE: DNA and RNA extracted from cryopreserved bone marrow cells and/or blood cells are
analyzed for mutations and gene expression signatures (genome-wide methylation, mRNA and
miRNA expression, and single nucleotide polymorphism (SNP) analysis) by microarray assays.
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