Leukemia Clinical Trial
Official title:
Promoter Methylation in MLL-Rearranged Childhood AML
RATIONALE: Studying samples of tissue from patients with cancer the in laboratory may help
doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in tissue samples from young patients
with acute myeloid leukemia.
OBJECTIVES:
- To determine whether the pattern of global and TSG-specific promoter CpG island
hypermethylation and gene silencing that we have shown characterizes MLL-rearranged
(MLL-r) infant bilineage ALL is also characteristic of other subsets of MLL-r leukemia.
OUTLINE: Previously collected cryopreserved cells from diagnosis are analyzed for promoter
methylation via HELP arrays, gene expression arrays, and RT-qPCR.
PROJECTED ACCRUAL: A total of 32 samples (8 from each of 4 biologically defined cohorts)
will be analyzed.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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