Leukemia Clinical Trial
Official title:
SCOR in Targeted Therapies for Infant Leukemias Project 2: Targeting Apoptosis in Leukemia in Infants
Verified date | May 2016 |
Source | Children's Oncology Group |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Observational |
RATIONALE: Studying the effects of obatoclax mesylate in cell samples from patients with
cancer in the laboratory may help doctors learn more about the effects of obatoclax mesylate
on cancer cells. It may also help doctors identify biomarkers related to cancer.
PURPOSE: This research study is studying obatoclax mesylate in samples from young patients
with acute myeloid leukemia.
Status | Completed |
Enrollment | 50 |
Est. completion date | |
Est. primary completion date | May 2016 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A to 2 Years |
Eligibility |
DISEASE CHARACTERISTICS: - Diagnosis of acute myeloid leukemia (AML) - Cryopreserved samples from infants with AML available PATIENT CHARACTERISTICS: - Not specified PRIOR CONCURRENT THERAPY: - Not specified |
Observational Model: Case-Only, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Children's Oncology Group | National Cancer Institute (NCI) |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Obatoclax mesylate activity | No | ||
Primary | Optimum in vitro combinations of obatoclax mesylate | No | ||
Primary | Pharmacodynamic (PD) biomarkers of activity | No | ||
Primary | Cell death mechanism in multiple-lineage leukemia (MLL) acute myeloid leukemia (AML) | No | ||
Primary | Disease progression in a xenograft model of MLL-rearranged infant AML | No | ||
Secondary | Physical assessment (in xenograft model) | No | ||
Secondary | Peripheral blast count reduction | No | ||
Secondary | Apoptosis and/or ATG induction | No | ||
Secondary | Modulation of relevant PD biomarkers | No |
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