Leukemia Clinical Trial
Official title:
Development of Novel Therapeutics for AMKL
RATIONALE: Studying samples of blood or tissue from patients with cancer in the laboratory
may help doctors learn more about changes that occur in DNA and identify biomarkers related
to cancer.
PURPOSE: This research study is studying biomarkers in samples from patients with Down
syndrome and acute megakaryoblastic leukemia.
OBJECTIVES:
- Determine whether megakaryocyte differentiation agents comprising a Rho kinase
inhibitor and a JAK3 inhibitor can lead to proliferation arrest, polyploidization, and
terminal differentiation of blasts in specimens from patients with Down syndrome and
acute megakaryoblastic leukemia.
OUTLINE: Cryopreserved specimens are cultured and treated in vivo (in mice) and in vitro
with megakaryocytic differentiation agents comprising a Rho kinase inhibitor and a JAK3
inhibitor.
;
Observational Model: Cohort, Time Perspective: Retrospective
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