Leukemia Clinical Trial
Official title:
EVI-1 Expression in Pediatric AML With 11q23 Abnormalities
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research study is looking at gene expression in tissue samples from young
patients with acute myeloid leukemia.
OBJECTIVES:
- Examine mRNA from pediatric patients with acute myeloid leukemia with 11q23
translocations by reverse transcriptase-PCR to quantify expression of EVI1 splice
variants.
OUTLINE: Cryopreserved mRNA from diagnostic samples is analyzed for gene expression by
reverse transcriptase-PCR.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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