Leukemia Clinical Trial
Official title:
Mechanisms of PLAGL2-Induced Leukaemogenesis
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research study is looking at gene expression in tissue samples from patients
with acute myeloid leukemia.
OBJECTIVES:
- Screen acute myeloid leukemia (AML) samples to correlate high relative expression
levels of PLAGL2 and putative PLAGL2 target genes (implicated in microarray study) with
potential pathogenic relevance with respect to AML development.
OUTLINE: Cryopreserved mRNA from diagnostic samples is analyzed for gene expression by
reverse transcriptase-PCR.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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