Leukemia Clinical Trial
Official title:
Molecular Mechanisms of NOTCH Induced Transformation in T-ALL
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This laboratory study is looking at tissue samples from patients with T-cell acute
lymphoblastic leukemia.
OBJECTIVES:
- Identify the transcriptional signatures associated with the presence of NOTCH1 mutations
in primary T-cell acute lymphoblastic leukemia (T-ALL) cells using oligonucleotide
microarrays.
- Characterize the global changes on gene expression resulting from the inactivation of
NOTCH signaling in human T-ALL lymphoblasts.
OUTLINE: This is a multicenter study.
Frozen lymphoblast samples from patients with T-cell acute lymphoblastic leukemia
(NOTCH1-mutated and wild type) are assessed for genetic expression profiles and mutations by
microarray analysis and activated NOTCH1 protein by western blot analysis.
PROJECTED ACCRUAL: A total of 48 samples from patients will be accrued for this study.
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