Leukemia Clinical Trial
Official title:
A Pilot Study to Characterize the Genomic and Epigenomic Signature of NPM Positive Vs. NPM Negative NCL
Verified date | July 2020 |
Source | Eastern Cooperative Oncology Group |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
It may also help doctors predict how well patients respond to treatment.
PURPOSE: This laboratory study is looking at tissue samples from patients with acute myeloid
leukemia.
Status | Completed |
Enrollment | 418 |
Est. completion date | October 15, 2009 |
Est. primary completion date | October 15, 2009 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 120 Years |
Eligibility |
DISEASE CHARACTERISTICS: - Diagnosis of acute myeloid leukemia - Enrolled on clinical trial ECOG-E1900 PATIENT CHARACTERISTICS: - Not specified PRIOR CONCURRENT THERAPY: - Not specified |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
ECOG-ACRIN Cancer Research Group | National Cancer Institute (NCI) |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Nucleophosmin exon 12 mutation-related normal cytogenetics leukemia (NCL) has a specific genetic and epigenetic profile | 1 day | ||
Primary | Relatedness on a per-gene basis of cross-platform data | 1 day | ||
Primary | Ability of supervised clustering to distinguish subgroups according to clinical prognostic and biomarker indicators | 1 day | ||
Primary | Ability of unsupervised clustering to identify subgroups of NCL patients | 1 day | ||
Primary | Relative power of each platform mentioned above vs the integrated platforms | 1 day |
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