Leukemia Clinical Trial
Official title:
Intensive Induction for Newly Diagnosed Acute Myelogenous Leukemia
RATIONALE: Drugs used in chemotherapy, such as mitoxantrone, cytarabine, and etoposide, work
in different ways to stop the growth of cancer cells, either by killing the cells or by
stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill
more cancer cells.
PURPOSE: This phase II trial is studying how well combination chemotherapy works in treating
patients with newly diagnosed acute myeloid leukemia.
OBJECTIVES:
- Determine the complete remission rate in patients with acute myelogenous leukemia
treated with induction chemotherapy comprising mitoxantrone hydrochloride, cytarabine,
and etoposide.
- Determine the feasibility and toxicity of this regimen when given to patients with
newly diagnosed acute myelogenous leukemia.
OUTLINE: Patients receive induction chemotherapy comprising mitoxantrone hydrochloride IV on
days 1-3, cytarabine IV continuously over 72 hours on days 1-3 and 8-10, and etoposide IV
continuously over 72 hours on days 8-10. Patients also receive filgrastim (G-CSF)
subcutaneously once daily beginning on day 4 and continuing until blood counts recover.
PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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