Leptospirosis Clinical Trial
Official title:
Serological Response in Patients Infected by Leptospirosis 1 to 7 Years Earlier
Leptospirosis is a zoonotic infection induced by pathogen bacteria (genus: Leptospira)
growing in water polluted by animal fluids. Due to its 10 fold occurence in French overseas
aera, and especially in Reunion Island, as compared to metropoly, it is considered as a
major public health issue.
An important inter-individual variability in humoral immune response suggests that
vaccination should be recommended in exposed subjects.
This cohort study aimed to determine if subjects that have been infected by leptospirosis
for 1 to 7 years still remain immunized, and then do not need vaccination.
Every year more than 500 000 severe forms of leptospirosis are diagnosed in Reunion Island.
The risk of mucocutaneous contact with contaminated media remains important due to highly
aqueous environment.
Cured subjects that have been infected for 1, 2, 3, 4, 5, 6 or 7 years will be enrolled. The
qualitative and quantitative humoral immune response to leptospirosis infection will also be
evaluated to determine whether they still get protective immunization. Leptospirosis
immunization will be evaluated using micro-agglutination test.
Graded immune responses related to the severity and the length of the infection will also be
investigated.
Finally, 3 methods used for leptospirosis diagnosis will be compared. It is expected from
this study to evaluate the appropriate conditions in which new vaccination could be required
to prevent further leptospirosis infection in cured subjects.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05425524 -
Leptospirosis Care Bundle Study
|
N/A | |
| Completed |
NCT03912506 -
Severe Leptospirosis in Non-tropical Areas
|
||
| Recruiting |
NCT04288674 -
Leptospirosis Registry - LeptoScope
|
||
| Recruiting |
NCT05300425 -
Seroprevalence of Leptospirosis in Val Müstair, Switzerland
|
||
| Completed |
NCT01080989 -
The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands
|
N/A | |
| Recruiting |
NCT05436756 -
Chronic Post-leptospirosis Manifestations in Reunion
|
N/A | |
| Recruiting |
NCT04882046 -
Study of the Incidence of Jarisch-Herxheimer Reaction in Leptospirosis Patients in New Caledonia
|
N/A | |
| Terminated |
NCT00592566 -
Desmopressin and Dexamethasone Adjunctive Treatment for Leptospirosis
|
Phase 2/Phase 3 | |
| Recruiting |
NCT04034550 -
Cohort of Hospitalized Patients Suspected of Leptospirosis
|
N/A | |
| Completed |
NCT05413720 -
Study of the Innate Immune Response to the Acute Phase of Human Leptospirosis - IMMUNOLEPTO
|
N/A | |
| Completed |
NCT01766830 -
Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)
|
N/A | |
| Recruiting |
NCT02000635 -
Study of Decreasing Kinetics of the Leptospiremia During Antibiotic Treatment of Leptospirosis in Martinique
|
||
| Active, not recruiting |
NCT01607047 -
French West Indies Leptospirosis Study
|
||
| Completed |
NCT03497572 -
Seroprevalence Study to Evaluate the Persistence of Anti-leptospira Antibody in Subjects Vaccinated With Spirolept® Vaccine
|