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Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis — CSI ProLong  

Leptomeningeal Metastasis Clinical Trial

Official title:
Phase II Study of Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis

Clinical Trial Summary

Leptomeningeal metastasis is a rare but serious complication to cancer, with a grave prognosis. No efficient treatment exists. Recent data suggest that craniospinal radiotherapy lead to superior survival and CNS control compared to focal photon radiotherapy. We want to offer Danish patients the new treatment, but within a protocol, as this is new data with an new treatment principle

Clinical Trial Description

Patients with leptomeningeal metastasis from both solid and hematological cancers will be offered proton radiotherapy with 30 Gy in 10 fractions to the entire craniospinal axis. Patients will be followed with registration of side effects, neurology and MRI scans every 3 months until 1 year. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05746754
Study type Interventional
Source University of Aarhus
Contact Kenneth Jensen, PhD
Phone +45 78 45 64 00
Email kennjens@rm.dk
Status Recruiting
Phase N/A
Start date November 1, 2023
Completion date April 1, 2031
View Details
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