Leiomyoma, Uterine Clinical Trial
Official title:
Mechanisms of Reduced Fertility in Women With Uterine Leiomyomas
We aim to explore some of the molecular factors that reduce fertility for women with leiomyomas, taking into account leiomyoma location, size, number and vascularity. Tissue samples from the endometrium and leiomyomas will be obtained during the mid secretory phase before and 3-6 months after surgical excision for a comprehensive search for key molecular derangements.
Baseline medical information and standard questionnaire to record symptoms are collected from
all participants and a gynaecological examination and a 2D and 3D vaginal ultrasonography
including saline infusion sonography (SIS), if indicated, are performed. Blood samples for
the biobank for extraction of germ line DNA and for identification of possible biomarkers are
taken.
The women with submucosal leiomyomas will undergo hysteroscopic myomectomy and the women with
intramural leiomyomas will undergo myomectomy per laparoscopy or laparotomy.
For the participants with intramural leiomyomas and the fertile/infertile controls,
endometrial samples are taken with an endometrial suction curette in an outpatient setting at
day 19-23 of the menstrual cycle. The endometrial sampling in the group of women with
submucosal leiomyomas is being done during the hysteroscopic removal of the leiomyoma, also
at day 19-23 of the menstrual cycle.
3-6 months after surgery, cycle day 19-23, endometrial samples will be taken from the women
who have undergone myomectomy and ultrasound examination is being performed. The women with
submucosal leiomyomas will undergo a second look hysteroscopy
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