Left Ventricular Dyssynchrony Clinical Trial
Official title:
Left Ventricular Dyssynchrony: Rest/Stress 3D Blood-Pool Gated D-SPECT Quantification With a High-Speed Dedicated Cardiac Camera Before CRT
Cardiac Resynchronization Therapy (CRT) is an established treatment for patients with
advanced heart failure and left ventricular dyssynchrony (LVD). Too many patients do not
clinically improve with CRT. New LVD markers other than QRS duration are needed.
Study objective : feasibility assessment of rest and real-time stress 3D Blood-Pool Gated
SPECT (BPGS) with a new designed cardiac imaging camera (DSPECT, Spectrum Dynamics®,
Ceasaria, Israel) to quantify LVD.
Sequential 5 min Gated blood pool D-SPECT acquisition at rest and during last stage of
dobutamine and atropin infusion (>85% PHR).
Rest and stress left ventricular ejection fraction, phase standard deviation and entropy
will be determined using a fully automatic commercial software (QBS, Cedars-Sinai, Los
Angeles, CA).
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Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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