Comparison of 2 Cefazolin Prophylactic Protocol in Laryngectomy Patients

Status Completed

Clinical Trial Summary

Patients who need major head & neck surgery are at risk of post operative wound infection. In spite of role of antibiotics in prophylaxis of clean contaminated head and neck surgery has been well documented, controversy exists in the optimal antibiotic regimen

Clinical Trial Description

Patients undergoing laryngeal oncologic surgery are at relatively high risk of developing complication.

Efficacy of cefazolin as a prophylactic antibiotic in head and neck surgery was reviewed in many researches [6] but considering the costs and morbidities of prolonged antibiotic regimen we have presented a prospective and randomized study in 90 patients comparing the efficacy of 2 day over 5 day protocols. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention

Related Conditions & MeSH terms

Laryngeal Cancer

Clinical Trial Details

NCT number	NCT00467948
Study type	Interventional
Source	Tehran University of Medical Sciences
Contact
Status	Completed
Phase	Phase 3
Start date	June 2004
Completion date	March 2006

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