Laparotomy Clinical Trial
Official title:
Perioperative Oxygen Fraction - Effects on the PaO2/FiO2-Index During Laparotomy
Aim: To investigate the effect of high intra- and postoperative oxygen concentration (80%,
as opposed to normally 30%) on pulmonary gas exchange and other pulmonary complications
after abdominal surgery.
Background: Previous studies have shown possible beneficial effects of high perioperative
oxygen concentration on surgical wound infection and healing, but all pulmonary effects are
not clarified. Change in perioperative PaO2/FiO2 and shunt-fraction, measured by a gas
rebreathing technique, can describe pulmonary oxygenation. This could add knowledge to the
pulmonary effects of high vs. normal oxygen concentration.
Primary hypothesis of study: Perioperative use of a 80% oxygen concentration reduces the
PaO2/FiO2-index compared to 30% oxygen.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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