Laparoscopy Clinical Trial
Official title:
Neoadjuvant Chemotherapy Followed by Radical Hysterectomy for the Treatment of Locally Advanced Cervical Cancer: A Prospective Cohort Study
This cohort study is to evaluate the role of neoadjuvant chemotherapy (NAC) in the treatment
of locally advanced cervical cancer (LACC). Sixty patients with LACC (FIGO 2009 stage IB2 to
IIB) will be enrolled. After informed consents, they would accept the imaging evaluation of
pelvic magnetic resonance imaging (MRI) and positron emission tomography (PET). After
excluding cases of distant metastasis, they will accept two cycles of NAC (paclitaxel 175
mg/m2 and cisplatin 70 mg/m2, on day 1, once for three weeks). Then a second MRI is performed
to evaluate the imaging response. For patients achieving objective response, radical
hysterectomy (RH, via laparoscopy or laparotomy) and an evaluation of pathologic response are
performed. For patients without objective imaging response, the choice of concurrent
chemoradiotherapy or radical hysterectomy will be discussed. After RH, adjuvant therapy will
be given according to the RH pathologic results.
The primary objectives consist of (1) the objective imaging response after NAC; (2) the
objective pathologic response after RH.
The secondary objectives consist of (1) disease-free survival and overall survival after
various therapy modalities; (2) severe adverse effects of NAC; (3) the effects of NAC on the
surgical outcomes.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT04515485 -
A Volumetric Nomogram for Height, Weight, and Intra Abdominal Volume
|
||
| Completed |
NCT01725477 -
Laparoscopic Tubal Patency Assessment
|
N/A | |
| Recruiting |
NCT01093079 -
Laparoscopic Versus Open Partial Nephrectomy - Surgical and Oncological Outcomes
|
N/A | |
| Recruiting |
NCT01093430 -
Is the Anterior Superior Iliac Spine a Useful Landmark at Laparoscopy?
|
N/A | |
| Completed |
NCT00535990 -
Minimally Invasive Surgery (MIS) Database for the Purpose of Research
|
||
| Completed |
NCT01092013 -
Comparative Evaluation of Simulator Based and Traditional In-surgery Laparoscopic Camera Training's Efficiency in Novices
|
N/A | |
| Recruiting |
NCT06044909 -
Multimodal Image Registration for Helping Laparoscopic Liver Surgery Guidance
|
||
| Not yet recruiting |
NCT05389241 -
Laparoscopic Augmented Reality for Identification of Liver Lesions - a Pre-clinical Randomized Cross-over Trial
|
N/A | |
| Completed |
NCT06255080 -
Comparing Skills Acquisition on Different Laparoscopy Software
|
N/A | |
| Enrolling by invitation |
NCT03234543 -
Remote Ischemic Conditioning in Abdominal Surgery
|
N/A | |
| Recruiting |
NCT02827292 -
Effect of Music on Inflammatory Response During Laparoscopic Surgery
|
N/A | |
| Not yet recruiting |
NCT06092684 -
The Efficacy and Safety of Esketamine in Elective Laparoscopic Surgery
|
Phase 3 | |
| Terminated |
NCT01008709 -
Comparison Study of Two Different Surgical Clips During Laparoscopic Urologic Surgery
|
N/A | |
| Active, not recruiting |
NCT05363813 -
Post-market Clinical Follow-up Study of Reusable Clip Applier Cartridge Devices for LAParoscopic Surgery
|
N/A | |
| Completed |
NCT03330236 -
EEG - Guided Anesthetic Care and Postoperative Delirium
|
N/A | |
| Recruiting |
NCT05031182 -
Tolerance of the vNOTES Surgical Technique in Total Hysterectomy for Benign Lesion. Clinical Trial of Non-inferiority Compared to the Laparoscopic Technique.
|
N/A | |
| Active, not recruiting |
NCT05302622 -
Detecting the Most Efficient Residency Time for Laparoscopic Simulators
|
N/A | |
| Recruiting |
NCT03684291 -
Hemodynamic Effects of Ventilation Modes
|
||
| Recruiting |
NCT06117748 -
Volume-Controlled Ventilation and Pressure-Controlled Ventilation Volume Guaranteed in Obese Patients in Laparoscopic-Assisted Surgery
|
N/A | |
| Recruiting |
NCT03739944 -
Different Surgical Approaches in Patients of Early-stage Cervical Cancer
|
Phase 3 |