Clearance Rate of Peritoneal Fluid After Full Conditioning Pneumoperitoneum

Laparoscopic Hysterectomy Clinical Trial

Official title: Clearance Rate of Peritoneal Fluid Assessed by Post-operative Ultrasound Decreases After Full Conditioning Pneumoperitoneum

Status Completed

Clinical Trial Summary

Measurement of residual peritoneal fluid after laparoscopic surgery

Clinical Trial Description

Primary endpoints

• to evaluate whether the clearance rate of peritoneal fluid is exponential or linear over time. (absorption rate expected for Adept ~30-60 ml/h)

• to evaluate the role of the mesothelial barrier in this clearance rate.

Knowing that diffusion to and from peritoneal fluid decreases with increasing molecular weight (MW), our hypothesis is that clearance rate will decrease following peritoneal conditioning. Indeed a decreased mesothelial trauma (either through hypoxia or through denudation) and retraction will expose less the basal membrane

Secondary endpoints:

-To confirm the decrease in post-operative pain as measured by VAS-score and inflammation as measured by CRP and leucocytosis with the full conditioning of the pneumoperitoneum. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Laparoscopic Hysterectomy
• Pneumoperitoneum

• NCT number: NCT01344499
• Study type: Interventional
• Source: University Hospital, Gasthuisberg
• Status: Completed
• Phase: N/A
• Start date: August 2009
• Completion date: September 2011