Langerhans Cell Histiocytosis Clinical Trial
Official title:
Safety and Efficacy of CD207 Targeted CAR-T Cell Therapy in Patients With Relapsed and Refractory (R/R) Langerhans Cell Histiocytosis
This is a single-arm study to evaluate the efficacy and safety of CD207 targeted CAR-T cell therapy in relapsed and refractory langerhans cell histiocytosis.
There are limited options for treatment of r/r langerhans cell histiocytosis. CD207 is expressed on the membrane surface of langerhans cells，and it is an ideal target for CAR-T. In this study, investigators will evaluate the safety and efficacy of CD207 targeted CAR- T cell therapy in patients with r/r langerhans cell histiocytosis. The primary goal is safety and efficiency assessment, including incidence and severity of adverse events and overall response rate. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03270020 -
Denosumab for the Treatment of Adult LCH
|
Phase 2 | |
| Recruiting |
NCT05997602 -
To Evaluate the Efficacy, Safety, and PK Characteristics of FCN-159 in Pediatric Patients With Refractory/Recurrent LCH
|
Phase 2 | |
| Recruiting |
NCT05915208 -
Histiocytic Disorder Follow-up Study
|
||
| Completed |
NCT03096782 -
Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma
|
Phase 2 | |
| Recruiting |
NCT04120519 -
Thalidomide, Cyclophosphamide and Dexamethasone for Recurrent/Refractory Adult Langerhans Cell Histiocytosis
|
Phase 2 | |
| Recruiting |
NCT04121819 -
AraC for Newly Diagnosed Adult Langerhans Cell Histiocytosis
|
Phase 2 | |
| Recruiting |
NCT05284942 -
Central China Rosai-Dorfman Disease Registry
|
Phase 4 | |
| Active, not recruiting |
NCT03220035 -
Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)
|
Phase 2 | |
| Completed |
NCT02608619 -
Uptake and Biodistribution of 18F-fluorocholine in Histiocytic Disorders by PET Imaging and Biopsy Measurement
|
||
| Completed |
NCT01395004 -
A Study to Test the Ability of and Safety of GSK2110183 in Treating Langerhans Cell Histiocytosis
|
Phase 2 | |
| Recruiting |
NCT02205762 -
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
|
Phase 2/Phase 3 | |
| Active, not recruiting |
NCT02425904 -
Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis and LCH-related Disorders
|
Phase 2 | |
| Recruiting |
NCT02670707 -
Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH)
|
Phase 3 | |
| Completed |
NCT02665546 -
Evaluation of Exercise Capacity and Exercise Limitation in Patients With Pulmonary Langerhans Cell Histiocytosis
|
||
| Recruiting |
NCT04627090 -
LCH in Adults: a Collaborative, Prospective-retrospective, Observational Study
|
||
| Recruiting |
NCT03585686 -
A Combination of Vemurafenib, Cytarabine and 2-chlorodeoxyadenosine in Children With LCH and BRAF V600E Mutation
|
Phase 2 | |
| Recruiting |
NCT03155620 -
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
|
Phase 2 | |
| Recruiting |
NCT04773366 -
A Prospective Study for the Treatment of Children With Newly Diagnosed LCH Using a Cytarabine Contained Protocol
|
Phase 3 | |
| Completed |
NCT02389400 -
Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis
|
Phase 2 | |
| Completed |
NCT00588536 -
Study of Sequential Administration of Oral 6-Thioguanine After Methotrexate in Patients With LCH
|
Phase 2 |