Langerhans Cell Histiocytosis Clinical Trial
Official title:
Thalidomide, Cyclophosphamide and Dexamethasone for Adult Patients With Recurrent/Refractory Langerhans Cell Histiocytosis: A Single Arm, Single Center, Prospective Phase 2 Study
Langerhans cell histiocytosis (LCH) is a rare, heterogeneous histiocytic disorder occurring most commonly in children. Because of the rarity of LCH in adults and a lack of prospective randomized trials, the treatment strategy for adults is mostly based on pediatric protocols. The overall response rate of therapy based on vinblastine plus prednisone in adults is lower than in children and the treatment tends to show higher toxicity.There is little data to guide therapy after frontline treatment. In a phase 2 trial, thalidomide as monotherapy gave a 70% response rate in recurrent/refractory low risk LCH but there were no responses in six high risk children. We want to analyze the efficacy and toxicity of thalidomide combined with dexamethasone and cyclophosphamide regimens in the treatment of recurrent/refractory LCH among adult patients at our hospital.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03270020 -
Denosumab for the Treatment of Adult LCH
|
Phase 2 | |
| Recruiting |
NCT05997602 -
To Evaluate the Efficacy, Safety, and PK Characteristics of FCN-159 in Pediatric Patients With Refractory/Recurrent LCH
|
Phase 2 | |
| Recruiting |
NCT05915208 -
Histiocytic Disorder Follow-up Study
|
||
| Completed |
NCT03096782 -
Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma
|
Phase 2 | |
| Not yet recruiting |
NCT05477446 -
Safety and Efficacy of CD207 Targeted CAR-T Cell Therapy in Patients With R/R Langerhans Cell Histiocytosis
|
Phase 1 | |
| Recruiting |
NCT04121819 -
AraC for Newly Diagnosed Adult Langerhans Cell Histiocytosis
|
Phase 2 | |
| Recruiting |
NCT05284942 -
Central China Rosai-Dorfman Disease Registry
|
Phase 4 | |
| Active, not recruiting |
NCT03220035 -
Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)
|
Phase 2 | |
| Completed |
NCT02608619 -
Uptake and Biodistribution of 18F-fluorocholine in Histiocytic Disorders by PET Imaging and Biopsy Measurement
|
||
| Completed |
NCT01395004 -
A Study to Test the Ability of and Safety of GSK2110183 in Treating Langerhans Cell Histiocytosis
|
Phase 2 | |
| Recruiting |
NCT02205762 -
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
|
Phase 2/Phase 3 | |
| Active, not recruiting |
NCT02425904 -
Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis and LCH-related Disorders
|
Phase 2 | |
| Recruiting |
NCT02670707 -
Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH)
|
Phase 3 | |
| Completed |
NCT02665546 -
Evaluation of Exercise Capacity and Exercise Limitation in Patients With Pulmonary Langerhans Cell Histiocytosis
|
||
| Recruiting |
NCT04627090 -
LCH in Adults: a Collaborative, Prospective-retrospective, Observational Study
|
||
| Recruiting |
NCT03585686 -
A Combination of Vemurafenib, Cytarabine and 2-chlorodeoxyadenosine in Children With LCH and BRAF V600E Mutation
|
Phase 2 | |
| Recruiting |
NCT03155620 -
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
|
Phase 2 | |
| Recruiting |
NCT04773366 -
A Prospective Study for the Treatment of Children With Newly Diagnosed LCH Using a Cytarabine Contained Protocol
|
Phase 3 | |
| Completed |
NCT02389400 -
Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis
|
Phase 2 | |
| Completed |
NCT00588536 -
Study of Sequential Administration of Oral 6-Thioguanine After Methotrexate in Patients With LCH
|
Phase 2 |