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Dichloroacetate Kinetics, Metabolism and Toxicology

Lactic Acidosis Clinical Trial

Clinical Trial Summary

Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.

Clinical Trial Description

n/a

Study Design

Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00015015
Study type Observational
Source National Institute of Environmental Health Sciences (NIEHS)
Contact
Status Completed
Phase N/A
Start date December 1994
Completion date October 2002
View Details
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