Lactase Persistence Clinical Trial
Official title:
Serum Lactate Trend in Liver Resection With Intermittent Pringle Maneuver: The "Square-Root" Shape
The study aimed to evaluate the correlation between the serum lactate concentration ed cumulative Pringle time after liver resection. In addition, the correlation between lactate clearance and clamping time was investigated.
During liver resection high serum lactate (sLac) concentration can be related to several
clinical factors: impairment in lactate metabolism (i.e. extraction and utilization by the
liver) or overproduction by splanchnic tissues; restrictive fluid regimen in order to limit
the intraoperative back-flow bleeding; ischemia-reperfusion syndrome. However, the Pringle
maneuver (temporary clamping of the hepatic hilum) seems having a sensible effect in
inducing a significant increase in sLac levels during liver resection, particularly in the
event of compromised liver function such as in cirrhosis.
Although the peak of sLac concentration may correlate with outcome, the lactate clearance
(cLac) seems to be a better predictor. To date, this relationship has been mainly
demonstrated in severe sepsis and shock septic. However, the effective correlation between
the cumulative clamping time and cLac has not been clearly investigated. The correlation
between cumulative hepatic ischemic time and sLac trend in the perioperative period after
liver resection with intermittent PM was investigated.
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Observational Model: Cohort, Time Perspective: Retrospective