Lacrimal Duct Obstruction Clinical Trial
Official title:
Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses
Verified date | September 2016 |
Source | University Hospital Ostrava |
Contact | n/a |
Is FDA regulated | No |
Health authority | Czech Republic: Ethics Committee |
Study type | Observational |
Background Because dacryoliths occur at low frequency, few studies have focused on their
composition.
The investigators aimed to present findings from morphological, chemical, and mineralogic
analysis of 86 dacryoliths.
Methods The team studied 86 dacryoliths obtained during 832 dacryocystorhinostomies (DCR)
performed for postsaccal obstruction. The samples were analyzed with atomic infrared
spectrometry (80 samples), amino acid analysis (17 samples), scanning electron microscopy,
and an electron microprobe with an energy dispersive detector (7 samples).
Status | Completed |
Enrollment | 86 |
Est. completion date | January 2013 |
Est. primary completion date | December 2012 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - patients over 18 years of age - patients complaining of lacrimation - patients following an extraction of a dacryolith Exclusion Criteria: - not signing the Informed Consent - high risk of surgery (ASA IV) - presaccal obstruction treatment - revision EDCRs - incomplete follow-ups |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Czech Republic | University Hospital Ostrava | Ostrava | Moravian-Silesian Region |
Lead Sponsor | Collaborator |
---|---|
University Hospital Ostrava |
Czech Republic,
Iliadelis E, Karabatakis V, Sofoniou M. Dacryoliths in chronic dacryocystitis and their composition (spectrophotometric analysis). Eur J Ophthalmol. 1999 Oct-Dec;9(4):266-8. — View Citation
Iliadelis ED, Karabatakis VE, Sofoniou MK. Dacryoliths in a series of dacryocystorhinostomies: histologic and chemical analysis. Eur J Ophthalmol. 2006 Sep-Oct;16(5):657-62. — View Citation
Lew H, Lee SY, Yun YS. Measurement of pH, electrolytes and electrophoretic studies of tear proteins in tears of patients with dacryoliths: a novel concept for dacryoliths. Ophthalmologica. 2004 Mar-Apr;218(2):130-5. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The percentage of individual types of amino-acids in the dacryolits | The obtained dacryolist were assessed physically and chemically. The authors will assess the obtained material for the presence of common amino acids. | 18 months | No |
Secondary | The percentage individual elements in the dacryolits | The obtained biological material will be assessed as regards to its elemental composition. | 18 months | No |
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