Labor Onset Clinical Trial
Official title:
Correlation Between Coital Activity During Pregnancy and Premature Delivery Related to Prostanoid Receptor Polymorphisms
The purpose of our study is correlate between premature delivery (between week 23-35 of the pregnancy) in women that had intercourse up to 12 hours prior to beginning of labor and polymorphisms in the gene Prostanoid receptor.
During the past years there has been a conflict between different studies regarding the
correlation between intercourse during pregnancy and early labor. Brustman et al showed that
women that were at a high risk for early delivery and had intercourse and then an early
labor had significantly increase uterine activity compared to women at low risk. Petridou et
al showed that this risk is significantly higher at week 33 of gestation. However, the
Cochrane Library summary leaves the question of correlation between intercourse and early
labor unanswered. In Sayle et al's study showed no correlation between early delivery and
intercourse. In 2004 Oguma described 3 polymorphisms in the Prostanoid receptor gene. These
polymorphisms were correlated to increased activity of smooth muscles of bronchi in asthma.
Since this gene is also expressed in the uterine muscles we wanted to determine whether
there is a correlation between the three polymorphisms T-549C, C-441T, T-197C, G+1044A and
early delivery due to intercourse.
1. Brustman LS, Raptoulis M. Langer O, Anyaegbunam A & Merkatz IR. Changes in the pattern
of uterine contractility in relationship to coitus during pregnancies at low and high
risk for preterm labor. Obstet Gynecol 1989;73:166-168
2. Petridou E, Salvnos H, Skalkidou A, Dessypris N, Moustaki M & Trichopoulos D. Are there
common triggers of preterm deliveries. British J Obst Gynecol 2001;108:598-604)
3. Kavanagh J, Kelly AJ & Thomas J. Sexual intercourse for cervical ripening and induction
of labour. The Cochrane Database of Systematic Reviews 2001, Issuse 2.Art.
No.:CD003093. DOI: 10.1002/14651858.CD003093
4. Sayle AE, Savitz DA, Thorp JM, Hertz-Picciotto I & Wilcox AJ. Sexual activity during
late pregnancy and risk of preterm delivery. Obstet Gynecol 2001;97:283-9)
5. Bernal AL. Mechanisms of labour-biochemical aspects. BJOG 2003;110(Supp 20):39-45
6. Oguma T, Palmer L, Birden E, Sonna LA, Asano K& Lilly CM. Role of prostanoid dp
receptor variants in susceptibility to asthma. NEJM 2004;351:1752-63
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