Knee Pain Clinical Trial
Official title:
Vitamin D Levels In Patients Who Has Normal to Grade 2 Knee Arthroscopy Changes or Who Did Not Improve Symptoms Following Minor Knee Arthroscopic Procedures
Verified date | March 2016 |
Source | Mid Essex Hospital NHS Trust |
Contact | n/a |
Is FDA regulated | No |
Health authority | United Kingdom: National Health Service |
Study type | Observational |
Vitamin D deficiency has long been linked to musculoskeletal pain, and many other chronic
disease conditions. Vitamin D is a nutrient that functions as a hormone precursor, and
wide-ranging health effects are supported by the presence of vitamin D receptors in several
cell types and tissues of the body (eg, lymphocytes and monocytes, brain, heart, pancreas,
intestine, and placenta).In addition to its essential role of maintaining bone health,
hypovitaminosis D has been implicated in the development of serious conditions, including
diabetes, various types of cancer, and cardiovascular diseases.
Vitamin D is a unique prohormone that humans obtain in small amount from food, dietary
supplements and largely by endogenous skin synthesis from 7-dehydrocholesterol with sunlight
exposure. This endogenous synthesis produces the form vitamin D3 (cholecalciferol).Vitamin D
deficiency and insufficiency are very common in the UK. Local audit at Chelmsford has shown
severe deficiency of vitamin D among chronic pain patients.
The major source of vitamin D synthesis relies on sunlight exposure which is likely to be
affected by modern lifestyles, which increasingly involve working indoors during daylight
hours. This may be particularly important when combined with residence in northern latitudes
and a cloudy climate.The proposed pilot study aims to identify percentage of vitamin D
deficiency among knee pain patients by investigating eligible patients' blood for '25
hydroxy vitamin D'.
English speaking patients whose knee pain has not been resolved following knee arthroscopy
are eligible for the study. Study will be carried out at the Broomfield hospital chronic
pain department.
Duration will be around 6 months.
Status | Terminated |
Enrollment | 2 |
Est. completion date | March 2014 |
Est. primary completion date | March 2014 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Male & no pregnant female age between 18-40 yrs, who continue to experience knee pain following normal to Grade 2 knee arthroscopy findings. Exclusion Criteria: - Any types of anatomical or neurological causes for the pain, history of seizures, regional pain syndrome, alcohol or drug abuse, and malignancy, patients with clinically significant diseases and patients who do not understand English will be excluded. |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United Kingdom | Broomfield Hospital | Chelmsford | Essex |
Lead Sponsor | Collaborator |
---|---|
Dr. S R Thanthulage |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The percentages of Vitamin D deficiency among the knee pain patients. | To identify the percentages of Vitamin D deficiency among the knee pain patients | 6months | No |
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