Effect of Short-term Motor Training on Accuracy and Precision of Knee Movement in Human With and Without Knee Pain

Knee Pain Chronic Clinical Trial

Official title:

Effect of Short-term Motor Training on Accuracy and Precision of Knee Movement in Human With and Without Knee Pain

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04146311
• Other study ID #: N-20170080
• Status: Completed
• Phase: N/A
• Start date: October 30, 2019
• Est. completion date: December 20, 2020

Study information

• Verified date: January 2021
• Source: Aalborg University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The objects of this research are to investigate the ability of the motor learning and test the possible differences between younger and older healthy human, and between non-pain and acute experimental pain and chronic clinical pain conditions.

Description:

The project consists of four experimental studies. In the first experiment, younger and older healthy human subjects are involved in a short-term neuromuscular training on the accuracy and precision of knee movement to investigate the possible age effect of the motor learning. The second experiment focuses on the experimental pain on the learning effect of the younger subjects. The third experiment will investigate a group of knee osteoarthritis patients to show the influence of chronic pain on the motor training compared with age-, gender-matched pain free subjects. 3D camera tracking system will be used to record the knee movements at the baseline and after 6-day motor task training. The variability in amplitude of the values of knee movements was transformed to percentage in relation to the target position (accuracy) or to the mean position (precision). The results of the study will contribute to both basic and clinical understanding of the mechanisms related to knee movement control and influences of varies painful conditions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: December 20, 2020
• Est. primary completion date: November 28, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• • Aged 18-30 or 50-65 years

• Free from ongoing or chronic pain

• Right dominant leg

• Speak and understand English

• Aged 50-65 years.

• Diagnosed with knee OA (according to American College of Rheumatology classification) with pain in left or both knees for more than six months

• Have ongoing pain rated above 2 on a 0-10 Visual Analogues Scale (VAS) in the previous week.

• Right dominant leg

• Speak and understand English

• Aged 50-65 years

• Diagnosed with knee OA

• Have had total knee arthroplasty on left or both knees

• Right dominant leg

• Speak and understand English

Exclusion Criteria:

• • Pregnancy or intent to become pregnant, breast feeding

• Regular use of analgesics, including simple analgesia and NSAIDs

• Frequent recreational drug or alcohol use

• History of knee joint pathology or injury

• Previous neurologic, musculoskeletal or mental illnesses

• Practicing sport activities on a regular basis

• Lack of ability to cooperate

• Regular use of analgesics, including analgesia and NSAIDs for the last 24 hours

• Frequent recreational drug or alcohol use

• Previous neurologic, musculoskeletal or mental illnesses

• Practicing sports activities on a regular basis

• Lack of ability to cooperate

• Regular use of analgesics, including analgesia and NSAIDs for the last 24 hours

• Frequent recreational drug or alcohol use

• Other disorders or injuries in the knee joints

• Previous neurologic, musculoskeletal or mental illnesses

• Practicing sports activities on a regular basis

• Lack of ability to cooperate

Related Conditions & MeSH terms

• Healthy Eld Human
• Hypertonic Saline
• Isotonic Saline
• Knee Pain Chronic

Intervention

Drug:
• Hypertonic saline
A bolus injection (0.25 ml) of hypertonic saline (5%) into the left infrapatellar fat pad.
• isotonic saline
A bolus injection (0.25 ml) of isotonic saline (5%) into the left infrapatellar fat pad.

Other:
• Motor training
All the subjects recruited need to have a short-term motor task training at home. 30 times a session, totally 2 sessions a day for 6 days

Locations

Country	Name	City	State
Denmark	Aalborg University	Aalborg

Sponsors (1)

Lead Sponsor	Collaborator
Aalborg University

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	knee movement assessment	There are two sessions in total, seperated by a 6 days motor training. Using 3D camera to calculate the accuracy and precision of knee movements at 30, 45, 60 degree respectively both with and without visual feedback (baseline), before and after motor training, also before and after injection.	Change from baseline, up to 7 days after the first session
Secondary	Assessment of pain	Immediately following the injection, participants will be instructed to rate the pain intensity for ten minutes using a digital visual analogue scale (VAS; eVas Software: Aalborg University, Denmark), on a tablet.The scale will be measured from 0 to10, where 0 represents 'no pain' and 10 represents 'worst pain imaginable'.	Only on day 7 (second session), up to 24 hours