Knee Injuries Clinical Trial
Official title:
Comparison Between Intra-articular Dexmedetomidine and Neostigmine as Adjuvant Analgesics After Knee Arthroscopy
Knee arthroscopy is a minimally invasive day case procedure which may be done for diagnosis, meniscectomy or debridement. Arthroscopic surgery is associated with a variable degree of postoperative pain, which is caused by an irritation of free nerve endings of the synovial tissue, anterior fat pad, and joint capsule due to surgical excision and resection
Many studies were done using different intra-articular agents as local anesthetics, opioids,
ketamine and alfa2- adrenergic agonists for prevention and treatment of pain after knee
surgeries.
Dexmedetomidine is a potent and highly selective alfa2-adrenoreceptor agonist. It has
sedative-hypnotic, anxiolytic, analgesic, anesthetic and sympatholytic effects.
Intra-articular dexmedetomidine was used in several studies to enhance postoperative
analgesia after knee arthroscopy with an increased time to first analgesic request and a
decreased need for postoperative analgesia Neostigmine is an anticholinesterase and also has
antinociceptive effects when administered intrathecally or peripherally.
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