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Large-scale Expansion and Characterization of Mesenchymal Stem Cells for Clinical Application

Knee Injuries Clinical Trial

Official title:
Large-scale ex Vivo Expansion and Characterization of Synovial Membrane Mesenchymal Stem Cells (SM-MSC) and Infrapatellar Fat Pad Mesenchymal Stem Cells (IF-MSC) for Clinical Application

Clinical Trial Summary

According to many recent research, mesenchymal stem cells (MSC) isolated from synovial membrane and infrapatellar fat pad have higher ex vivo proliferation capacity, multipotency and ability to undergo chondrogenesis.

Based on this concept, the investigators plan to get two removed tissues (synovial membrane and infrapatellar fat pad) from patients who have an operation of total knee replacement. The investigators are going to isolate and expand MSC from these two tissues respectively, and then compare the chondrogenesis ability for clinical application. In the other hand, the investigators plan to build techniques and procedures which comply with "Good Tissue Practices (GTP)"

Clinical Trial Description

n/a

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02375568
Study type Observational
Source Far Eastern Memorial Hospital
Contact Chih-Hung Chang, MD, Ph.D
Phone 886-2-89667000
Email orthocch@mail.femh.org.tw
Status Recruiting
Phase N/A
Start date May 2014
Completion date August 2015
View Details
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