Knee Alignment Contributions to Anterior Cruciate Ligament (ACL) Injury

Knee Injuries Clinical Trial

Official title:

Tibiofemoral Alignment: Contributing Factors to Noncontact Anterior Cruciate Ligament Injury

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00855023
• Other study ID #: 07-08-229-147
• Status: Completed
• Start date: November 2007
• Est. completion date: October 2010

Study information

• Verified date: March 2009
• Source: The Orthopaedic Center, Maryland
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study evaluates the the anatomic factors of the knee that may predispose to ACL injury.

Description:

Despite intense study of anterior cruciate ligament injury during the past three decades, the mechanisms of this injury have not been clearly defined. A recent study by the Principle Investigator identified differences in leg alignment when a single leg landing during a sports activity resulted in a torn ACL and when it did not (provocative versus control alignment, respectively).

The purpose of the study is to quantify the tibiofemoral alignment in the lateral compartment of the knee in the provocative landing position and the control landing position. in order to elucidate possible mechanisms of ACL injury Material and Methods: 25 normal controls will be recruited from the greater Washington DC population. Magnetic resonance images in the sagittal plane will be acquired for a single leg of each subject. These images will cover the lateral compartment of the knee and will be acquired with the leg in three positions, one that emulates the injury position, one that exagerrates the injury position, and one that emulates the control landing position. Statistical analysis of the measurements between the provocative, exagerrated provocative, and control positions will then be performed.

These insights could then be applied to improving training focused on reducing the incidences of ACL rupture; improving bracing designs to help athletes most at risk of ACL rupture or those recovering from ACL injury/surgery; and improving ACL replacement surgeries.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: October 2010
• Est. primary completion date: October 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Healthy controls

• Ages 18-45 years old

Exclusion Criteria:

• Previous knee injury or surgery

• Metal implants in body

Related Conditions & MeSH terms

• Knee Injuries
• Wounds and Injuries

Locations

Country	Name	City	State
United States	Open MRI of Washington	Rockville	Maryland

Sponsors (1)

Lead Sponsor	Collaborator
The Orthopaedic Center, Maryland

Country where clinical trial is conducted

United States, 

References & Publications (1)

Boden BP, Torg JS, Knowles SB, Hewett TE. Video analysis of anterior cruciate ligament injury: abnormalities in hip and ankle kinematics. Am J Sports Med. 2009 Feb;37(2):252-9. doi: 10.1177/0363546508328107. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Measurement of anatomy of knee		1 hour