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Impact of P-gp, MRP2, ENT-1 and CNT3 on the Blood Concentration / Intra-PBMC Concentration of Tacrolimus — TRANS-TAC  

Kidney Transplantation Clinical Trial

Official title:
Study of the Impact of P-gp, MRP2, ENT-1 and CNT3 on the Blood Concentration / Intra-PBMC Concentration of Tacrolimus in Liver and Kidney Transplant Patients

Clinical Trial Summary

Prospective and monocentric pharmacokinetic study

Clinical Trial Description

Membrane transporters supporting tacrolimus at the lymphocyte level may play a role in the variability of the relationship between tacrolimus blood concentration and intracellular concentration, or may be the main explanatory factors. Nevertheless, most of the studies carried out on the subject, have been by genetic approach, neglecting in fact the membrane expression of these transporters, which could testify more to the real effect on the transport of tacrolimus. A better understanding of the cellular transport mechanisms of tacrolimus in the T lymphocyte could thus make it possible to identify sub-populations of patients under-exposed at the intra-lymphocyte level, despite satisfactory systemic exposure. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03910868
Study type Observational
Source Rennes University Hospital
Contact
Status Completed
Phase
Start date July 16, 2020
Completion date December 16, 2020
View Details
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