Kidney Transplant; Complications Clinical Trial
— FOSTIKOfficial title:
Furosemide Stress Test as a Marker of Postoperative Kidney Allograft Function
NCT number | NCT03071536 |
Other study ID # | IRB 317/59 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | November 25, 2016 |
Est. completion date | May 2027 |
Furosemide is an old drug that has been used frequently in the postoperative period of kidney transplantation, aiming to achieve adequate urine output. There is no previous study that directly evaluate the urine response to standardized dose of furosemide in the postoperative period. The objective is to measure the urine output after standardized dose of furosemide is delivered, as a biomarker to predict the graft function in perioperative period.
Status | Recruiting |
Enrollment | 180 |
Est. completion date | May 2027 |
Est. primary completion date | May 2026 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Deceased donor kidney transplantation at KCMH - informed consent is accepted Exclusion Criteria: - Known allergy to furosemide - Surgical complication of allograft - Urgently needed for dialysis (refractory hypervolemia, uremic symptoms, and hyperkalemia) |
Country | Name | City | State |
---|---|---|---|
Thailand | King Chulalongkorn Memorial Hospital | Bangkok |
Lead Sponsor | Collaborator |
---|---|
King Chulalongkorn Memorial Hospital |
Thailand,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Urine output | Urine output per hour (milliliters/hour) after furosemide injection | 6 hours | |
Secondary | Delayed graft function | Delayed graft function is defined by the necessity of dialysis within the first week after kidney transplantation. (yes/no) | 7 days | |
Secondary | Creatinine reduction ratio | Ratio of serum creatinine at postoperative day 7 and 14 to day-zero creatinine | At postoperative day 0,7 and 14 |
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