Efficacy of Belatacept in Reducing DSA

Status Completed

Clinical Trial Summary

The primary objective of this study is to demonstrate that administration of belatacept in maintenance kidney transplant recipients may cause a reduction in Donor Specific HLA Antibody (DSA).

Clinical Trial Description

The aim of this study is to evaluate patients converted to belatacept in combination with MMF with corticosteroids with respect to their DSA titer. Patients in this study will be converted from their CNI to belatacept from baseline in an attempt to down-modulate antibody production by B-cells. Dosing will be calculated per prescribing information for dosing maintenance phase (5mg per kg every 28 days. ;

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Kidney Transplantation

Clinical Trial Details

NCT number	NCT02078193
Study type	Interventional
Source	East Carolina University
Contact
Status	Completed
Phase	Phase 4
Start date	November 2013
Completion date	July 2016

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